How Intermittent Fasting Improves Long Term Memory - Amandean

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July 19, 2021 5 min read

In this article:

  • The many health benefits of intermittent fasting
  • Intermittent fasting & the brain
  • Intermittent fasting & long-term memory function

The Many Health Benefits of Intermittent Fasting

Have you ever wondered how the meal "breakfast" got its name? If you break the word down, it literally means to “break a fast,” a period of time without food intake. Short fasts, or intermittent fasts, are built into our schedules. In modern times, the period between dinner and breakfast the next day is the longest fast most of us experience. Our bodies actually thrive during these brief fasting windows. In fact, your brain and body may benefit from adding more short-term fasts to your schedule!

Intermittent fasting (IF) is a more formalized version of the fast between dinner and breakfast or lunch. Though many people view IF as a diet or form of calorie restriction, there really is no "intermittent fasting diet", it's simply an eating schedule. There are many different fasting regimens including:

  • The 16:8:Sixteen hours of fasting followed by an eight-hour eating window
  • The 5:2:Five days of regular calorie intake and two days of caloric restriction
  • Alternate day fasting: One 24-hour fast, followed by a day with normal, healthy, calorie intake

Typically weight loss is the first benefit that comes to mind when considering intermittent fasting. Though intermittent fasting is not a restricted diet, it does often lead to better calorie control and weight loss. However, the positive effects of intermittent fasting are not limited to regulating your body weight! The benefits of intermittent fasting also include:

  • Improved insulin resistance
  • Increased fat burning(due to forced metabolic switching from glucose/carbohydrates to fatty acids and ketones)
  • Decreased levels of inflammation
  • Improved digestion and gut health
  • Noticeable improvements in skin clarity and texture
  • Energy boost and improved mental clarity
  • Increased metabolism
  • Lowered blood pressure and cholesterol
  • Improved cardiovascular health
  • Boosted brain health

Intermittent Fasting & The Brain

Both human and animal studies have found intermittent fasting can improve cognitive function in many different ways:

  • Reduced risk of Alzheimer's Disease and Parkinson’s: During a fast (usually after 19-24 hours) the body enters what is known as autophagy, or cellular cleanup. This helps to remove cellular waste, damaged proteins, and dead cells which have been known to collect in between nerve cells and lead to cognitive impairment and cellular dysfunction, including those that lead to the progression of Alzheimer's disease.
  • Brightens mood: Researchfound that study participants experienced improved moods and decreased tension, anger, and confusion after 3 months of intermittent fasting.
  • Reduces inflammation:Chronic, long-term inflammation is a risk factor to many brain disorders including depression, bipolar disorder, dementia, schizophrenia, Parkinson's disease, Alzheimer’s disease, and more. Numerous studies have found IF suppresses neuroinflammation and may be a promising preventative measure against neurodegenerative diseases.

Intermittent fasting has wonderful short-term benefits as well. Many entrepreneurs, athletes, and celebrities, including Terry Crews, choose intermittent fasting to improve their mental clarity and help them power through their days. Fasting removes a layer of "option overload" from your day and eliminates post lunch lethargy, bloatedness and sugar crashes. In fact, many people feel moreenergized and focused while fasting, almost as if a weight has been lifted. Entrepreneurs in fast-paced environments are turning to IF as a natural productivity booster. In an article at Entrepreneur.com, Cam Secore, a silicon-valley insider and owner of tech review site All Power Moves, stated "numerous tech enthusiasts utilize Kevin Rose's app called 'Zero' to track their fasting. It's free, it works, but it's most useful because it creates accountability."

Kyle Boelte, an author who follows the 5:2 method of IF, also stated "I’ve been intermittent fasting for a year now, and I no longer need an afternoon nap. I’m not irritable if I haven’t eaten in the past couple of hours, which used to happen to me all the time."

Breaking away from the "trap" of the world's 3 meal-per-day system can be scary at first, but many people find it liberating, especially for those who want mental clarity and energy today, and better cognition and memory later in life.

Intermittent Fasting & Long-Term Memory Function

A promising new study found intermittent fasting may also improve long term memory retention.

A study by the Institute of Psychiatry, Psychology and Neuroscience (IoPPN) was conducted on mice at King’s College London. In this study, researchers split female mice into three groups; a control group that received a standard, ad libitum diet of daily feeding, a second group that was on a daily 10% calorie restricted diet, and a third group on alternate-day intermittent fasting diet. After just three months, the brain structure of the mice was evaluated and studies measuring memory loss were conducted. In the end, it was found that mice in the IF group showed improved long-term memory retention compared to the other groups. They were able to conclude that intermittent fasting "enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho."

So how does IF work for the brain and what do these studies really mean? The hippocampus is known to be crucial for long-term memory. This study highlighted that even when compared to the caloric restrictive group, the mice on the IF diet were found to have enhanced hormone activity in the Klotho gene and more new neurons in the hippocampus, two critical components of slowing and preventing cognitive decline in older people. While researchers Dr. Sandrine Thuret and Gisele Pereira Dias shared that they hope to replicate the study on humans, they noted that just a 10% restriction of calories resulted in a significant difference in long term memory. They believe this shows great promise as a way to slow neurodegeneration and stimulate the production of new brain cells in humans as well.

Intermittent fasting is growing in popularity both in the scientific, and health and wellness arenas. While more studies and clinical trials focused on intermittent fasting's role in preserving human cognition need to be conducted, its short and long-term pay-offs make it well worth a try.

Summary Points

  • Though many people view IF as a diet or form of calorie restriction, there really is no "intermittent fasting diet", it's simply an eating schedule
  • Numerous studies have found IF suppresses neuroinflammation and may be a promising preventative measure against neurodegenerative diseases
  • Many entrepreneurs, athletes, and celebrities, including Terry Crews, choose intermittent fasting to improve their mental clarity and help them power through their days
  • A promising new study found intermittent fasting may also improve long term memory retention



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